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Protein that plays role in muscle formation identified

Alternative splicing (the process during gene expression that generates multiple proteins from a single gene) plays an important role in many developmental processes. In muscle formation, it has been known that this process occurs in multiple genes when muscle cells called myoblasts fuse to become fibers called myotubes; however, not much is known about the mechanisms that coordinate this process. Researchers at Baylor College of Medicine have now identified a protein Rbfox2 that regulates alternative splicing during this step.

Funding: Funding for the study came from: the American Heart Association (12POST11770017, 11SDG4980011); the Myotonic Dystrophy Foundation; the Ford Foundation; Baylor Research Advocates for Student Scientists (BRASS); the National Institutes of Health (R01HG007538, R01HL045565, R01AR060733, R01AR045653); and the Muscular Dystrophy Association.

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