Researchers at Oregon Health & Science University have successfully demonstrated a new gene therapy method to prevent certain inherited diseases in human cells for the first time. It’s believed that this research, along with other efforts, will pave the way for future clinical trials in human subjects.
The research was published in the highly respected journal Nature. The gene therapy method was initially devised through research in nonhuman primates led by OHSU’s Shoukhrat Mitalipov, Ph.D.
“Cell mitochondria contain genetic material just like the cell nucleus and these genes are passed from mother to infant,” explained Mitalipov. “When certain mutations in mitochondrial DNA are present, a child can be born with severe conditions, including diabetes, deafness, eye disorders, gastrointestinal disorders, heart disease, dementia and several other neurological diseases. Because mitochondrial-based genetic diseases are passed from one generation to the next, the risk of disease is often quite clear. The goal of this research is to develop a therapy to prevent transmission of these disease-causing gene mutations.”
Funding: The human oocyte/embryo research was supported by grants from the OHSU Center for Women’s Health Circle of Giving and additional private funds from OHSU as well as the Leducq Foundation and the OHSU Vice President for Research office. The nonhuman primate study was supported by grants from the National Institutes of Health.
- siddharthdvd2 likes this
- thatsroughkid likes this
- healthandmedicineorg reblogged this from medresearch
- molecularmick likes this
- csosebee likes this
- furrywolf316 likes this
- modifiedcat likes this
- rev320productions likes this
- kit-kat1598 likes this
- littleredridingborg likes this
- texasdreamer01 reblogged this from medresearch
- vickycrazybutinlove reblogged this from medresearch
- texasdreamer01 likes this
- katie437 submitted this to medresearch